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A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase

7 May 2013

Abstract excerpt

Viral RNA helicases are involved in duplex unwinding during the RNA replication of the virus. It is suggested that these helicases represent very promising antiviral targets. Viruses of the flaviviridae family are the causative agents of many common and devastating diseases, including hepatitis, yellow fever and dengue fever. As there is currently no available anti-Flaviviridae therapy, there is urgent need for...

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PMID: 23678398
DOI: 10.7717/peerj.74

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