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Article

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Journal of chemical information and modeling - 25 Nov 2013

Barakat Khaled H, Law John, Prunotto Alessio, Magee Wendy C, Evans David H, Tyrrell D Lorne, Tuszynski Jack, Houghton Michael

Abstract excerpt

The hepatitis C virus (HCV) RNA polymerase, NS5B, is a leading target for novel and selective HCV drug design. The enzyme has been the subject of intensive drug discovery aimed at developing direct acting antiviral (DAA) agents that inhibit its activity and hence prevent the virus from replicating its genome. In this study, we focus on one class of NS5B inhibitors, namely nucleos(t)ide mimetics. Forty-one...

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Identifiers

PMID: 24116674
DOI: 10.1021/ci4003969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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