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Article

Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites.

The Journal of biological chemistry - 1 Mar 2026

Mingroni Michael A, Enney Brooke M, Malsick Lauren E, Geiss Brian J

Abstract excerpt

Non-structural protein 13 (nsp13), the Coronaviral RNA helicase, is an attractive antiviral target due to its importance in viral genome replication and highly conserved nature. Nsp13's processive dsRNA unwinding is driven by ATP hydrolysis in the nucleotide triphosphatase active site, which provides mechanical energy through conformational changes in the helicase domain to unidirectionally break hydrogen bonds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41581884
DOI: 10.1016/j.jbc.2026.111198
PMCID: PMC12930049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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