Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.

Journal of virology - 15 Sept 2020

Du Pont Kelly E, Sexton Nicole R, McCullagh Martin, Ebel Gregory D, Geiss Brian J

Abstract excerpt

The unwinding of double-stranded RNA intermediates is critical for the replication and packaging of flavivirus RNA genomes. This unwinding activity is achieved by the ATP-dependent nonstructural protein 3 (NS3) helicase. In previous studies, we investigated the mechanism of energy transduction between the ATP and RNA binding pockets using molecular dynamics simulations and enzymatic characterization. Our data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culex
Share to Culicidae
Share to Flavivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Domains and Motifs

Share to RNA Helicases

Share to Vero Cells

Share to West Nile Fever

Share to West Nile virus

Source

Open in PubMed Open full text

Identifiers

PMID: 32699093
DOI: 10.1128/JVI.01021-20
PMCID: PMC7495370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.PMID 32699093Read ↗

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in MosquitoesSemantic proximity Read ↗

Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleftSemantic proximity Read ↗

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcriptionSemantic proximity Read ↗

Conserved motifs in the flavivirus NS3 RNA helicase enzymeSemantic proximity Read ↗

TMEM41B Is a Pan-flavivirus Host Factor.Semantic proximity Read ↗

RNA helicases in infection and diseaseSemantic proximity Read ↗

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.Semantic proximity Read ↗

Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites.Semantic proximity Read ↗

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymeraseSemantic proximity Read ↗

Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus.Semantic proximity Read ↗

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3XSemantic proximity Read ↗

An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.