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Article

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.

Biochemical and biophysical research communications - 22 Apr 2016

Lee Chien-Hsing, Huang Po-Tsang, Liou Horng-Huei, Lin Mei-Ying, Lou Kuo-Long, Chen Chung-Yi

Abstract excerpt

The ROMK1 (Kir1.1) channel activity is predominantly regulated by intracellular pH (pHi) and phosphatidylinositol 4,5-bisphosphate (PIP2). Although several residues were reported to be involved in the regulation of pHi associated with PIP2 interaction, the detailed molecular mechanism remains unclear. We perform experiments in ROMK1 pHi-gating with electrophysiology combined with mutational and structural...

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Identifiers

PMID: 27016482
DOI: 10.1016/j.bbrc.2016.03.100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.PMID 27016482Read ↗

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