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Article

Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2008

Ureche Oana N, Baltaev Ravshan, Ureche Liviu, Strutz-Seebohm Nathalie, Lang Florian, Seebohm Guiscard

Abstract excerpt

The Kir2 channels belong to a family of potassium selective channels with characteristic strong inward rectification. Heteromeric assemblies of Kir2.1, Kir2.2 and Kir2.3 channels underly membrane potential stabilizing currents in ventricular myocytes, neurons and skeletal muscle. Kir2 channels differ substantially in their sensitivity to extracellular pH. The extracellular histidine Kir2.3(H117) contributes to...

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PMID: 18453743
DOI: 10.1159/000129629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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