Article
The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.
The Journal of biological chemistry - 20 Jun 2008
Clarke Catherine E, Veale Emma L, Wyse Ken, Vandenberg Jamie I, Mathie Alistair
Abstract excerpt
Channels of the two-pore domain potassium (K2P) family contain two pore domains rather than one and an unusually long pre-pore extracellular linker called the M1P1 loop. The TASK (TASK1, TASK3, and TASK5) subfamily of K2P channels is regulated by a number of different pharmacological and physiological mediators. At pH 7.4 TASK3 channels are selectively blocked by zinc in a manner that is both pH(o)- and...
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