Article
Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2022
Snyder Julia P, Gullickson Soyeon K, Del Rio-Guerra Roxana, Sweezy Andrea, Vagher Bay, Hogan Tyler C, Lahue Karolyn G, Reisz Julie A, D'Alessandro Angelo, Krementsov Dimitry N, Amiel Eyal
Abstract excerpt
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO-mediated inhibition of mitochondrial respiration. This phenomenon primarily has been studied in DCs from the classic laboratory inbred mouse strain C57BL/6J (B6) mice, where DCs experience a loss of mitochondrial function due to...
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