Article

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

2025-04-26

Abstract excerpt

<h4>Background: </h4> Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary microvascular loss and obliterative remodeling, driven by metabolic reprogramming, oxidative stress, and endothelial dysfunction. While BMPR2 mutations contribute to metabolic shifts in pulmonary microvascular endothelial cells (PMVECs), their low penetrance suggests additional genetic modifiers play a r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e05c0f0a-95e9-5bb7-b01c-21b383b4f2db
DOI: 10.1101/2025.04.25.650735

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSIONDOI 10.1101/2025.04.25.650735Read

BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension.Semantic proximity Read

Rewriting the Vascular Script: Epigenetic Modifiers as Scribes of Metabolic Reprogramming in Pulmonary HypertensionSemantic proximity Read

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary HypertensionSemantic proximity Read

Role of endothelial microRNA-150 in pulmonary arterial hypertensionSemantic proximity Read

Time-resolved mitochondrial-focused screening identifies regulatory components of oxidative metabolismSemantic proximity Read

Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesitySemantic proximity Read

Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosisSemantic proximity Read

Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.Semantic proximity Read

<i>EPHX1</i> mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescenceSemantic proximity Read

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary HypertensionSemantic proximity Read

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB SignalingSemantic proximity Read

iPSC-Derived Endothelial Cells Reveals LDLR-Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read