Article
Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity.
Cell death & disease - 18 Oct 2024
de Lima Jean, Leite Jefferson Antônio, Basso Paulo José, Ghirotto Bruno, Martins da Silva Eloisa, Menezes-Silva Luisa, Hiyane Meire Ioshie, Goes Carolina Purcell, Coutinho Luiz Lehmann, de Andrade Oliveira Vinicius, Olsen Saraiva Câmara Niels
Abstract excerpt
Sirtuin 1 (SIRT1) is a class III histone deacetylase (HDAC3) that plays a crucial role in regulating the activation and differentiation of dendritic cells (DCs) as well as controlling the polarization and activation of T cells. Obesity, a chronic inflammatory condition, is characterized by the activation of immune cells in various tissues. We hypothesized that SIRT1 might influence the phenotype and functions of...
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