Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

Abstract excerpt

Distinguishing real biological variation in the form of single-nucleotide variants (SNVs) from errors is a major challenge for genome sequencing technologies. This is particularly true in settings where SNVs are at low frequency such as cancer detection through liquid biopsy, or human somatic mosaicism. State-of-the-art molecular denoising approaches for DNA sequencing rely on duplex sequencing, where both strands...

Topics

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• Cell-Free Nucleic Acids
• Circulating Tumor DNA
• Genomics
• High-Throughput Nucleotide Sequencing
• Melanoma
• Mutation
• Sequence Analysis, DNA
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

7648093c-d06f-590e-afb1-77416cf9c486

DOI

10.1101/2025.08.11.669689