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Article

Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses.

Nature genetics - 1 Jun 2024

Ojima Takafumi, Namba Shinichi, Suzuki Ken, Yamamoto Kenichi, Sonehara Kyuto, Narita Akira, Kamatani Yoichiro, Tamiya Gen, Yamamoto Masayuki, Yamauchi Toshimasa, Kadowaki Takashi, Okada Yukinori

Abstract excerpt

Type 2 diabetes (T2D) shows heterogeneous body mass index (BMI) sensitivity. Here, we performed stratification based on BMI to optimize predictions for BMI-related diseases. We obtained BMI-stratified datasets using data from more than 195,000 individuals (nT2D = 55,284) from BioBank Japan (BBJ) and UK Biobank. T2D heritability in the low-BMI group was greater than that in the high-BMI group. Polygenic...

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PMID: 38862855
DOI: 10.1038/s41588-024-01782-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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