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Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.

Diabetes, obesity & metabolism - 1 Aug 2025

Aliyu Usama, Umlai Umm-Kulthum Ismail, Al-Thani Nayra M, Toor Salman M, Abou-Samra Abdul Badi, Albagha Omar M E

Abstract excerpt

AIMS: To identify susceptibility loci to prediabetes and evaluate the performance of existing polygenic risk scores (PGS) for type 2 diabetes (T2D) in predicting prevalent prediabetes and progression to diabetes. MATERIALS AND METHODS: We conducted a case-control Genome-Wide Association Study (GWAS) on Qatar Biobank (QBB) participants with prediabetes (n = 2267) and normoglycaemia (n = 8665). We further evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40468860
DOI: 10.1111/dom.16490
PMCID: PMC12232356

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GCK
HK1

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