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Article

Molecular mechanism of BMP signal control by Twisted gastrulation.

Nature communications - 11 Jun 2024

Malinauskas Tomas, Moore Gareth, Rudolf Amalie F, Eggington Holly, Belnoue-Davis Hayley L, El Omari Kamel, Griffiths Samuel C, Woolley Rachel E, Duman Ramona, Wagner Armin, Leedham Simon J, Baldock Clair, Ashe Hilary L, Siebold Christian

Abstract excerpt

Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic development, kidney regeneration and cancer. We report crystal structures of TWSG1 alone and in complex with a BMP ligand, Growth Differentiation Factor 5. TWSG1 is composed of two...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38862520
DOI: 10.1038/s41467-024-49065-8
PMCID: PMC11167000

Genes

TWSG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Molecular mechanism of BMP signal control by Twisted gastrulation.PMID 38862520Read ↗

The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Semantic proximity Read ↗

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain developmentSemantic proximity Read ↗

An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation.Semantic proximity Read ↗

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis.Semantic proximity Read ↗

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.Semantic proximity Read ↗

The expression of twisted gastrulation in postnatal mouse brain and functional implications.Semantic proximity Read ↗

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Semantic proximity Read ↗

Identification of a second Xenopus twisted gastrulation gene.Semantic proximity Read ↗

Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.Semantic proximity Read ↗

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crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.Semantic proximity Read ↗

Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.Semantic proximity Read ↗

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