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Article

Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2009

Sotillo Rodriguez Julio E, Mansky Kim C, Jensen Eric D, Carlson Ann E, Schwarz Toni, Pham Lan, MacKenzie BreAnne, Prasad Hari, Rohrer Michael D, Petryk Anna, Gopalakrishnan Rajaram

Abstract excerpt

The uncoupling of osteoblastic and osteoclastic activity is central to disorders such as osteoporosis, osteolytic malignancies, and periodontitis. Numerous studies have shown explicit functions for bone morphogenetic proteins (BMPs) in skeletogenesis. Their signaling activity has been shown in various contexts to be regulated by extracellular proteins, including Twisted gastrulation (TWSG1). However, experimental...

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Identifiers

PMID: 19419314
DOI: 10.1359/jbmr.090507
PMCID: PMC2765934

Genes

TWSG1
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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