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Article

The pro-BMP activity of Twisted gastrulation is independent of BMP binding.

Development (Cambridge, England) - 1 Sept 2003

Oelgeschläger Michael, Reversade Bruno, Larraín Juan, Little Shawn, Mullins Mary C, De Robertis E M

Abstract excerpt

The determination of the vertebrate dorsoventral body axis is regulated in the extracellular space by a system of interacting secreted molecules consisting of BMP, Chordin, Tolloid and Twisted Gastrulation (Tsg). Tsg is a BMP-binding protein that forms ternary complexes with BMP and Chordin. We investigated the function of Tsg in embryonic patterning by generating point mutations in its two conserved...

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Identifiers

PMID: 12874126
DOI: 10.1242/dev.00633
PMCID: PMC2277362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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