Article
Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.
Development (Cambridge, England) - 1 Jan 2005
Xie Jing, Fisher Shannon
Abstract excerpt
BMP signaling is modulated by a number of extracellular proteins, including the inhibitor Chordin, Tolloid-related enzymes (Tld), and the interacting protein Twisted Gastrulation (Tsg). Although in vitro studies have demonstrated Chordin cleavage by Tld enzymes, its significance as a regulatory mechanism in vivo has not been established in vertebrates. In addition, Tsg has been reported in different contexts to...
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