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Article

Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.

Molecular and cellular biology - 1 Apr 2003

Nosaka Tetsuya, Morita Sumiyo, Kitamura Hidetomo, Nakajima Hideaki, Shibata Fumi, Morikawa Yoshihiro, Kataoka Yuki, Ebihara Yasuhiro, Kawashima Toshiyuki, Itoh Tsuneo, Ozaki Katsutoshi, Senba Emiko, Tsuji Kohichiro, Makishima Fusao, Yoshida Nobuaki, Kitamura Toshio

Abstract excerpt

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4 (BMP-4). However, TSG function in vivo is still unclear. We isolated a TSG cDNA as a secreted molecule from the mouse aorta-gonad-mesonephros region. Here we show that TSG-deficient mice were born healthy, but more...

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Source

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Identifiers

PMID: 12665593
DOI: 10.1128/MCB.23.8.2969-2980.2003
PMCID: PMC152550

Genes

SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.PMID 12665593Read ↗

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The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Semantic proximity Read ↗

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.Semantic proximity Read ↗

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BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalizationSemantic proximity Read ↗

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis.Semantic proximity Read ↗

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