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Article

An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation.

Development (Cambridge, England) - 15 Aug 2026

Moore Gareth, Revici Raluca, Forbes Beadle Lauren, Sutcliffe Catherine, Birchenough Holly, Baldock Clair, Ashe Hilary L

Abstract excerpt

During dorsoventral patterning of bilaterian embryos, the conserved regulator Twisted gastrulation (Tsg) modulates BMP signalling by binding Chordin/Short gastrulation (Sog). Here, we elucidate the mechanism by which Tsg interacts with Sog/Chordin to promote formation of the inhibitory Tsg-Sog/Chordin-BMP complex and regulate BMP signalling extracellularly. We identify and validate in vitro a hydrophobic...

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Identifiers

PMID: 41503687
DOI: 10.1242/dev.204584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation.PMID 41503687Read ↗

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Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain developmentSemantic proximity Read ↗

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Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.Semantic proximity Read ↗

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