Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.

doi:10.1016/j.bone.2006.06.028

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Article

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.

Bone - 1 Dec 2006

Gazzerro Elisabetta, Deregowski Valerie, Stadmeyer Lisa, Gale Nickolas W, Economides Aris N, Canalis Ernesto

Abstract excerpt

Twisted gastrulation (Tsg) is a secreted glycoprotein that binds bone morphogenetic proteins (BMP)-2 and -4 and can display both BMP agonist and antagonist functions. Tsg promotes BMP-mediated endochondral ossification, but its activity in adult bone is not known. We created tsg null mice and examined the consequences of the tsg deletion on the skeleton in vivo and on osteoblast function in vitro. Analysis of the...

Topics

Animals
Base Sequence
Bone Morphogenetic Proteins
Bone and Bones
Cells, Cultured
DNA, Complementary
Female
Gene Targeting
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Osteoblasts

Osteocalcin

Phenotype

Proteins

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 16934545
DOI: 10.1016/j.bone.2006.06.028

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Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.PMID 16934545Read ↗

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