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Article

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest.

Genetics - 7 Oct 2024

Di Bernardo Mercedes, León Guerrero Victoria L, Sutoski Jacob C, Hardy William Rod, MacNeil Lesley T

Abstract excerpt

Shc (Src homologous and collagen) proteins function in many different signaling pathways where they mediate phosphorylation-dependent protein-protein interactions. These proteins are characterized by the presence of two phosphotyrosine-binding domains, an N-terminal PTB and a C-terminal SH2. We describe a previously unrecognized Caenorhabditis elegans Shc gene, shc-3 and characterize its role in stress response....

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Identifiers

PMID: 38861412
DOI: 10.1093/genetics/iyae093
PMCID: PMC11630764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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