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Article

HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span

16 Oct 2014

Abstract excerpt

The conserved heat shock transcription factor-1 (HSF-1) is essential to cellular stress resistance and life-span determination. The canonical function of HSF-1 is to regulate a network of genes encoding molecular chaperones that protect proteins from damage caused by extrinsic environmental stress or intrinsic age-related deterioration. In Caenorhabditis elegans, we engineered a modified HSF-1 strain that...

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PMID: 25324391
DOI: 10.1126/science.1253168

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