Article

Acute-stress impairs cytoprotective mechanisms through neural inhibition of the insulin pathway

2018-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Persistent activation of the “fight-or-flight” response accelerates aging and increases the susceptibility to disease. We show that repeated induction of the C. elegans flight response inhibits conserved cytoprotective mechanisms. This acute-stress response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 p...

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Literature Corpus work: a356fb8b-be87-5735-81fc-eb928d5c3c48
DOI: 10.1101/294645

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