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Article

C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival.

Genes & development - 15 Aug 2006

Kritikou Ekaterini A, Milstein Stuart, Vidalain Pierre-Olivier, Lettre Guillaume, Bogan Erica, Doukoumetzidis Kimon, Gray Phillip, Chappell Thomas G, Vidal Marc, Hengartner Michael O

Abstract excerpt

During oocyte development in Caenorhabditis elegans, approximately half of all developing germ cells undergo apoptosis. While this process is evolutionarily conserved from worms to humans, the regulators of germ cell death are still largely unknown. In a genetic screen for novel genes involved in germline apoptosis in Caenorhabditis elegans, we identified and cloned gla-3. Loss of gla-3 function results in...

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Identifiers

PMID: 16912277
DOI: 10.1101/gad.384506
PMCID: PMC1553210

Genes

GLA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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