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Article

Day + 30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML.

BMC medicine - 3 Mar 2026

Jiang Shan, Feng Dan, Wan Li, Yang Nan, Ma Jiao, Cao Jiaxin, Pan Pan, Zheng Yawei, Cao Yigeng, Cao Wenbin, Liang Chen, Chen Xin, Zhang Rongli, Ma Qiaoling, Wei Jialin, Zhai Weihua, Yang Donglin, He Yi, Feng Sizhou, Han Mingzhe, Yao Yao, Pang Aiming, Jiang Erlie

Abstract excerpt

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved outcomes in patients with acute myeloid leukemia (AML) harboring FLT3-internal tandem duplication (FLT3-ITD) mutations. However, relapse still occurs in 15-35% of these patients after transplantation. Therefore, early and highly sensitive detection methods are required to identify patients at risk of relapse and enable timely...

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Share to fms-Like Tyrosine Kinase 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

Share to Neoplasm, Residual

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Source

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Identifiers

PMID: 41772567
DOI: 10.1186/s12916-026-04744-9
PMCID: PMC13063694

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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