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Article

Successive next-generation sequencing strategy for optimal fusion gene detection in non-small-cell lung cancer in clinical practice.

Pathology - 1 Aug 2024

Garinet Simon, Lupo Audrey, Denize Thomas, Loyaux Romain, Timsit Sarah, Gazeau Benoit, Fabre Elizabeth, Maaradji Zineb, Gibault Laure, Giroux-Leprieur Etienne, Duchemann Boris, Monnet Isabelle, Jouveshomme Stéphane, Aldea Mihaela, Besse Benjamin, Le Pimpec-Barthes Françoise, Leroy Karen, Wislez Marie, Blons Hélène

Abstract excerpt

Metastatic non-small-cell lung cancer (NSCLC) displays various molecular alterations in the RAS-MAPK pathway. In particular, NSCLCs show high rates of targetable gene fusion in ALK, RET, ROS1, NRG1 and NTRK, or MET exon 14 skipping. Rapid and accurate detection of gene fusion in EGFR/KRAS/BRAF mutations is important for treatment selection especially for first-line indications. RNA-based next-generation...

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PMID: 38834439
DOI: 10.1016/j.pathol.2024.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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