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Clinical Validation of a Targeted RNA-Sequencing Assay for Driver Gene Alteration Detection in Non-Small Cell Lung Cancer.

Molecular diagnosis & therapy - 1 May 2025

Li Ji, Shi Xiaohua, Zhang Hui, Lin Xiaojing, Zheng Shan, Chen Weizhi, Zhou Yang, Liang Zhiyong

Abstract excerpt

BACKGROUND AND OBJECTIVE: With the increasing number of diagnostic biomarkers associated with tumor diagnosis, targeted therapy, and immunotherapy, access to clinical pathological specimens of an appropriate size for analysis is becoming a problem. Conventional high-throughput sequencing assays for non-small cell lung cancer (NSCLC) often necessitate the extraction of separate DNA and RNA samples to achieve...

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PMID: 40087257
DOI: 10.1007/s40291-025-00774-w

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