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Article

Clinical framework for next generation sequencing based analysis of treatment predictive mutations and multiplexed gene fusion detection in non-small cell lung cancer.

Oncotarget - 23 May 2017

Lindquist Kajsa Ericson, Karlsson Anna, Levéen Per, Brunnström Hans, Reuterswärd Christel, Holm Karolina, Jönsson Mats, Annersten Karin, Rosengren Frida, Jirström Karin, Kosieradzki Jaroslaw, Ek Lars, Borg Åke, Planck Maria, Jönsson Göran, Staaf Johan

Abstract excerpt

Precision medicine requires accurate multi-gene clinical diagnostics. We describe the implementation of an Illumina TruSight Tumor (TST) clinical NGS diagnostic framework and parallel validation of a NanoString RNA-based ALK, RET, and ROS1 gene fusion assay for combined analysis of treatment predictive alterations in non-small cell lung cancer (NSCLC) in a regional healthcare region of Sweden (Scandinavia). The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28415793
DOI: 10.18632/oncotarget.16276
PMCID: PMC5471012

Genes

ALK
ROS1
KRAS
RET
TST
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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