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Optimising fusion detection through sequential DNA and RNA molecular profiling of non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2021

Moore David A, Benafif Sarah, Poskitt Benjamin, Argue Stephanie, Lee Siow-Ming, Ahmad Tanya, Papadatos-Pastos Dionysis, Jamal-Hanjani Mariam, Bennett Philip, Forster Martin D

Abstract excerpt

OBJECTIVES: There is an increasing number of driver fusions in NSCLC which are amenable to targeted therapy. Panel testing for fusions is increasingly appropriate but can be costly and requires adequate good quality biopsy material. In light of the typical mutual exclusivity of driver events in NSCLC, the objective of this study was to trial a novel testing pathway, supported by industrial collaboration, in which...

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PMID: 34536732
DOI: 10.1016/j.lungcan.2021.08.008

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