Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing.

doi:10.1016/j.jtho.2020.01.019

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Article

Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2020

Cohen Danielle, Hondelink Liesbeth M, Solleveld-Westerink Nienke, Uljee Sandra M, Ruano Dina, Cleton-Jansen Anne-Marie, von der Thüsen Jan H, Ramai S Rajen S, Postmus Pieter E, Graadt van Roggen Jacob F, Hoppe Bart P C, Clahsen Pieter C, Maas Klaartje W, Ahsmann Els J M, Ten Heuvel Alexandra, Smedts Frank, van Rossem Ronald N, van Wezel Tom

Abstract excerpt

INTRODUCTION: Frequently, patients with locally advanced or metastatic NSCLC are screened for mutations and fusions. In most laboratories, molecular workup includes a multitude of tests: immunohistochemistry (ALK, ROS1, and programmed death-ligand 1 testing), DNA sequencing, in situ hybridization for fusion, and amplification detection. With the fast-emerging new drugs targeting specific fusions and exon-skipping...

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PMID: 32014610
DOI: 10.1016/j.jtho.2020.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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