Article
Simultaneous detection of single-nucleotide variant, deletion/insertion, and fusion in lung and thyroid carcinoma using cytology specimen and an RNA-based next-generation sequencing assay.
Cancer cytopathology - 1 Mar 2018
Guseva Natalya V, Jaber Omar, Stence Aaron A, Sompallae Krishnaveni, Bashir Amani, Sompallae Ramakrishna, Bossler Aaron D, Jensen Chris S, Ma Deqin
Abstract excerpt
BACKGROUND: Molecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. Fine-needle aspiration (FNA)-derived material frequently is the only pathologic material available. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.