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Article

Generalized genetic liability to substance use disorders.

The Journal of clinical investigation - 3 Jun 2024

Miller Alex P, Bogdan Ryan, Agrawal Arpana, Hatoum Alexander S

Abstract excerpt

Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and compared with individual SUDs is characterized by greater severity, additional psychiatric comorbidities, and worse outcomes. Here, we review evidence for the role of generalized genetic liability to various SUDs. Coaggregation of SUDs has familial contributions, with twin studies suggesting a strong contribution of additive...

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Identifiers

PMID: 38828723
DOI: 10.1172/JCI172881
PMCID: PMC11142744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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