Polygenic risk scores reveal genetic underpinnings of comorbidity between substance use disorders and ADHD.

doi:10.1016/j.euroneuro.2026.112799

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Article

Polygenic risk scores reveal genetic underpinnings of comorbidity between substance use disorders and ADHD.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2026

Horstman Lisa I, Koller Dora, Cabana-Domínguez Judit, Llonga Natalia, Icick Romain, Vorspan Florence, Grau-López Lara, van den Brink Wim, Fóthi Ábel, Barta Csaba, Ramos-Quiroga Josep A, Kaye Sharlene, Farrell Michael, Allsop Steve, Brynte Christoffer, Franck Johan, van Emmerik-van Oortmerssen Katelijne, Demetrovics Zsolt, Kapitány-Fövény Máté, Matthys Frieda I A, Dom Geert, Ribases Marta, Schellekens Arnt

Abstract excerpt

One in five people attending services with a substance use disorder (SUD) also has comorbid attention-deficit/hyperactivity disorder (ADHD). While some evidence shows that shared heritability might partly explain this frequent comorbidity, studies on this topic are scarce. Therefore, the goal of this study was to test whether ADHD and SUD have shared genetic influences. A total of 1,513 SUD treatment-seeking...

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Share to Attention Deficit Disorder with Hyperactivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Identifiers

PMID: 41762898
DOI: 10.1016/j.euroneuro.2026.112799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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