Phenotypic and genetic relations between attention-deficit/hyperactivity disorder and substance use disorders.

doi:10.1017/S0033291725103103

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Article

Phenotypic and genetic relations between attention-deficit/hyperactivity disorder and substance use disorders.

Psychological medicine - 18 Sept 2026

Setzer Michael, Kember Rachel, Hartwell Emily, Piserchia Zachary, Gelernter Joel, Kranzler Henry, Gray Joshua

Abstract excerpt

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUDs) commonly co-occur and have overlapping genetic liabilities. Less is known regarding the phenomenology and genetics of ADHD in a cohort enriched for SUDs and the extent to which ADHD genetic liability contributes to SUD risk when controlling for substance specific genetic risk. METHODS: We used data from the Yale-Penn...

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Topics

Humans
Attention Deficit Disorder with Hyperactivity
Substance-Related Disorders
Phenotype
Genetic Risk Score
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Multifactorial Inheritance

Genetic Predisposition to Disease

Comorbidity

Adult

Adolescent

Age of Onset

Young Adult

Cohort Studies

Source

Open in PubMed

Identifiers

PMID: 42755248
DOI: 10.1017/S0033291725103103

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