Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies.

Behavior genetics - 1 Jul 2011

Hicks Brian M, Schalet Benjamin D, Malone Stephen M, Iacono William G, McGue Matt

Abstract excerpt

Using large twin, family, and adoption studies conducted at the Minnesota Center for Twin and Family Research, we describe our efforts to develop measures of substance use disorder (SUD) related phenotypes for targets in genome wide association analyses. Beginning with a diverse set of relatively narrow facet-level measures, we identified 5 constructs of intermediate complexity: nicotine, alcohol consumption,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoption
Share to Alcoholism
Share to Diseases in Twins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Behavioral

Share to Mental Disorders

Share to Minnesota

Share to Psychometrics

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 21153693
DOI: 10.1007/s10519-010-9417-2
PMCID: PMC3123412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies.PMID 21153693Read ↗

Three mutually informative ways to understand the genetic relationships among behavioral disinhibition, alcohol use, drug use, nicotine use/dependence, and their co-occurrence: twin biometry, GCTA, and genome-wide scoring.Semantic proximity Read ↗

The genetic architecture of substance use and its diverse correlations with mental health traits.Semantic proximity Read ↗

Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling.Semantic proximity Read ↗

Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin studySemantic proximity Read ↗

Generalized genetic liability to substance use disorders.Semantic proximity Read ↗

Index of the transmissible common liability to addiction: heritability and prospective associations with substance abuse and related outcomes.Semantic proximity Read ↗

Genetically informative research on adolescent substance use: methods, findings, and challenges.Semantic proximity Read ↗

Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability.Semantic proximity Read ↗

Phenotypic and genetic relations between attention-deficit/hyperactivity disorder and substance use disorders.Semantic proximity Read ↗

Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects across Multiple CohortsSemantic proximity Read ↗

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.Semantic proximity Read ↗

Genome-wide single nucleotide polymorphism heritability of nicotine dependence as a multidimensional phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.