Article

Genetic liability to addiction underlies comorbid bipolar and substance use disorders

2026-02-05

Abstract excerpt

<h4>Background</h4> Bipolar disorder (BIP) frequently co-occurs with heightened substance use (SU) and substance use disorders (SUDs). Although the strong co-occurrence of these heritable traits points to shared genetic susceptibility, the extent to which there are differences in how SU and SUD overlap with BIP genetic architecture remains unclear. <h4>Methods</h4> We quantified the polygenic overlap between BIP...

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Literature Corpus work: 575c4b81-b0f8-5090-85dd-b76b043bd43c
DOI: 10.64898/2026.02.04.26345483

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