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Article

KnockoffHybrid: A knockoff framework for hybrid analysis of trio and population designs in genome-wide association studies.

American journal of human genetics - 11 Jul 2024

Yang Yi, Wang Qi, Wang Chen, Buxbaum Joseph, Ionita-Laza Iuliana

Abstract excerpt

Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid analysis of both...

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Identifiers

PMID: 38821058
DOI: 10.1016/j.ajhg.2024.05.003
PMCID: PMC11267528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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