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Article

Common Genetic Variants in TRIO Are Associated With Autism in Chinese Han Population.

Genetics research - 1 Jan 2025

Shen Han, Sun Xiaoxuan, Wang Ziqi, Jiang Miaomiao, Wang Jinxin, Lu Tianlan, Yue Weihua, Zhang Dai, Wang Lifang, Li Jun

Abstract excerpt

Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders with high heritability. Nevertheless, the involvement of genetic variants in ASDs is not fully understood. One gene of interest is TRIO, which encodes a large protein that aids in GDP-to-GTP exchange as a Ras homologous (Rho) guanine nucleotide exchange factor (GEF), facilitating cytoskeleton reorganization. Thus, it plays crucial roles...

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Source

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Identifiers

PMID: 41438617
DOI: 10.1155/genr/7762302
PMCID: PMC12721762

Genes

TRIO
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Common Genetic Variants in TRIO Are Associated With Autism in Chinese Han Population.PMID 41438617Read ↗

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An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio.Semantic proximity Read ↗

Mutations specific to the Rac-GEF domain of <i>TRIO</i> cause intellectual disability and microcephalySemantic proximity Read ↗

Extending the phenotypes associated with TRIO gene variants in a cohort of 25 patients and review of the literature.Semantic proximity Read ↗

De Novo TRIO Missense Variants Disrupt Ras-GEF Domains and Cause Congenital Ventriculomegaly and Hydrocephalus.Semantic proximity Read ↗

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Heterozygosity for neurodevelopmental disorder-associated <i>TRIO</i> variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in miceSemantic proximity Read ↗

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