Article
Interaction-integrated linear mixed model reveals 3D-genetic basis underlying Autism.
Genomics - 1 Mar 2023
Li Qing, Perera Deshan, Cao Chen, He Jingni, Bian Jiayi, Chen Xingyu, Azeem Feeha, Howe Aaron, Au Billie, Wu Jingjing, Yan Jun, Long Quan
Abstract excerpt
Genetic interactions play critical roles in genotype-phenotype associations. We developed a novel interaction-integrated linear mixed model (ILMM) that integrates a priori knowledge into linear mixed models. ILMM enables statistical integration of genetic interactions upfront and overcomes the problems of searching for combinations. To demonstrate its utility, with 3D genomic interactions (assessed by Hi-C...
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