Article

Gamete simulation improves polygenic transmission disequilibrium analysis

2020-10-27

Abstract excerpt

Polygenic risk scores (PRS) derived from summary statistics of genome-wide association studies (GWAS) have enjoyed great popularity in human genetics research. Applied to population cohorts, PRS can effectively stratify individuals by risk group and has promising applications in early diagnosis and clinical intervention. However, our understanding of within-family polygenic risk is incomplete, in part because the...

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Literature Corpus work: e2eea366-4558-54a2-9327-e60091494de2
DOI: 10.1101/2020.10.26.355602

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