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Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

30 May 2024

Abstract excerpt

Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and why these differences arise. Somatic genomic aberrations occur within the context of a highly variable germline genome. Interrogating 5870 breast cancer lesions, we demonstrated that germline-derived epitopes in recurrently amplified genes influence somatic evolution by mediating...

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PMID: 38815010
DOI: 10.1126/science.adh8697

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