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Article

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

1 May 2019

Abstract excerpt

The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones,...

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Identifiers

PMID: 31141692
DOI: 10.1016/j.celrep.2019.04.098

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