Article
Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.
Nature communications - 5 Dec 2022
Sivakumar Smruthy, Jin Dexter X, Tukachinsky Hanna, Murugesan Karthikeyan, McGregor Kimberly, Danziger Natalie, Pavlick Dean, Gjoerup Ole, Ross Jeffrey S, Harmon Robert, Chung Jon, Decker Brennan, Dennis Lucas, Frampton Garrett M, Molinero Luciana, Oesterreich Steffi, Venstrom Jeffrey M, Oxnard Geoffrey R, Hegde Priti S, Sokol Ethan S
Abstract excerpt
Pathological and genomic profiling have transformed breast cancer care by matching patients to targeted treatments. However, tumors evolve and evade therapeutic interventions often through the acquisition of genomic mutations. Here we examine patients profiled with tissue (TBx) and liquid biopsy (LBx) as part of routine clinical care, to characterize the tumor evolutionary landscape and identify potential...
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