Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Abstract excerpt

Disruption of antigen presentation via loss of MHC expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy. We developed the personalized genomics algorithm Hapster and accurately called somatic mutations within the MHC genes of 10,001 primary and 2,199 metastatic tumors, creating a catalog of 1663 nonsynonymous mutations that provide key insights into MHC m...

Topics

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• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II
• HLA Antigens
• Immunotherapy and Immune Responses
• Mutation
• Neoplasms
• T-Lymphocytes
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

030bf66a-24e3-5f36-9e90-c45fc7db00b0

DOI

10.1101/2023.01.22.523447