Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress.

Abstract excerpt

Protein aggregation is mostly viewed as deleterious and irreversible causing several pathologies. However, reversible protein aggregation has recently emerged as a novel concept for cellular regulation. Here, we characterize stress-induced, reversible aggregation of yeast pyruvate kinase, Cdc19. Aggregation of Cdc19 is regulated by oligomerization and binding to allosteric regulators. We identify a region of low...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Cycle
• Share to Cell Cycle Proteins
• Share to Protein Aggregates