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Glucose intake hampers PKA-regulated HSP90 chaperone activity

5 Dec 2018

Abstract excerpt

Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are still elusive. Here, we conducted a quantitative mass spectrometry screen and identified all...

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PMID: 30516470
DOI: 10.7554/elife.39925

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