Article

Phosphorylation of Ser81 in human AGT reversibly inactivate enzyme function and mimics catalytic defects of certain PH1-causing mutations

2025-04-19

Abstract excerpt

Phosphorylation is fundamental to modulate protein function and stabilty. There have detected about 300000 site-specic Phosphorylation sites in over 20000 human proteins. However, only 5% of the sites have been experimenrally characterized. In this work, we investigated a phosphorylation event in AGT, an important enzyme due to its detoxifying role of glyoxylate and hundreds of mutations cause a rare disease (prim...

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Literature Corpus work: 5d66cce3-c476-598b-8ba8-17128bc8d466
DOI: 10.1101/2025.04.14.648764

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