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Article

Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Apr 2026

Belaïdouni Yasmine, Diabira Diabe, Salin Pascal, Brosset-Heckel Mélanie, Valsamides Victoria, Graziano Jean-Charles, Santos Catarina, Menuet Clément, Wayman Gary A, Gaiarsa Jean-Luc

Abstract excerpt

Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by mutations in MECP2. Elevated circulating levels of the adipocyte hormone leptin are consistently observed in patients and in mouse models, yet their contribution to disease progression has remained unclear. Here, we show that reducing leptin signaling-either pharmacologically or genetically-significantly alleviates RTT-like phenotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

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Source

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Identifiers

PMID: 42001766
DOI: 10.1016/j.neurot.2026.e00910
PMCID: PMC13098445

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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