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Article

Protein phosphatase PP1 regulation of RNA polymerase II transcription termination and allelic exclusion of VSG genes in trypanosomes.

Nucleic acids research - 8 Jul 2024

Kieft Rudo, Zhang Yang, Yan Haidong, Schmitz Robert J, Sabatini Robert

Abstract excerpt

The genomes of Leishmania and trypanosomes are organized into polycistronic transcription units flanked by a modified DNA base J involved in promoting RNA polymerase II (Pol II) termination. We recently characterized a Leishmania complex containing a J-binding protein, PP1 protein phosphatase 1, and PP1 regulatory protein (PNUTS) that controls transcription termination potentially via dephosphorylation of Pol II...

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Identifiers

PMID: 38783162
DOI: 10.1093/nar/gkae392
PMCID: PMC11229358

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