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Article

Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei.

mBio - 5 Feb 2025

Kieft Rudo, Cliffe Laura, Yan Haidong, Schmitz Robert J, Hajduk Stephen L, Sabatini Robert

Abstract excerpt

Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and changes in gene expression are entirely post-transcriptional. Trypanosoma brucei brucei is unable to infect humans because of its susceptibility to an innate immune complex, trypanosome lytic factor...

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Identifiers

PMID: 39704500
DOI: 10.1128/mbio.02328-24
PMCID: PMC11796357

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